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Please contact us if you would like to contribute a news item. We are keen to publish more articles from UK-based research and findings that relate to microbial infections during therapy.

Many of the deadliest cancers receive the least amount of research funding

7/8/2019

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'Embarrassing' or stigmatized cancers like lung and liver are underfunded
  • Poorly funded cancers: colon, endometrial, liver and bile duct, cervical, ovarian, pancreatic and lung
  • Well-funded cancers: breast, pediatric, leukemia and lymphoma
  • All cancers with stigmatized behavior (i.e. lung cancer and smoking) are poorly funded
  • Underfunding of these common cancers could negatively impact research, drug development
Picture
Scatter plots using logarithmic scales for both the x and y axes of annual revenue versus mortality. CREDIT Northwestern University
Many of the deadliest or most common cancers get the least amount of nonprofit research funding, according to a new Northwestern Medicine study that examined the distribution of nonprofit research funding in 2015 across cancer types.

Colon, endometrial, liver and bile duct, cervical, ovarian, pancreatic and lung cancers were all poorly funded compared to how common they are and how many deaths they cause, the study found. In contrast, breast cancer, leukemia, lymphoma and pediatric cancers were all well-funded, respective to their impact on society.

The study is the first to compare nonprofit funding distribution in the United States across cancer types. It will be published  in the Journal of the National Comprehensive Cancer Network.

"The goal of this study is not to divert funds away from cancers that are well-supported, but rather expand funding for other cancers that aren't getting enough support currently," said corresponding author Dr. Suneel Kamath, who was the chief fellow in the department of hematology and oncology at Northwestern University Feinberg School of Medicine when he conducted the study. "These are all deadly and life-altering diseases that deserve our attention and support."

Cancer-related nonprofit organizations play an important role in funding medical research, supporting the education of patients and their families and influencing health policy. Underfunding of these common cancers could negatively impact research, drug development and the number of FDA drug approvals for poorly funded cancers.
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"Well-funded patient advocacy organizations should be applauded for their successes," said co-author Dr. Sheetal Kircher, assistant professor of hematology and oncology at Feinberg and a Northwestern Medicine oncologist. "We hope to bring awareness to the organizations with less relative funding so we can collaborate to improve funding and outcomes for all patients with cancer."

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Genetic differences between strains of Epstein-Barr virus can alter its activity

6/8/2019

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Genetic differences between the two main strains of the blood cancer-triggering virus have been shown to change the way the virus behaves when it infects white blood cells.
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Solution structures of type 1 and type EBV EBNA2-BS69 complexes determined by small angle X-ray scattering. Type 2 EBNA2 binds an extra BS69 molecule (dimer). CREDIT Michelle West, University of Sussex
Researchers at the University of Sussex have identified how differences in the genetic sequence of the two main strains of the cancer-associated Epstein-Barr virus (EBV) can alter the way the virus behaves when it infects white blood cells.

When EBV enters white blood cells it drives them to grow rapidly and continuously, making them 'immortal'. In some cases this can lead to the development of lymphoma, a type of blood cancer.
There are two main strains of the virus worldwide and although they can both cause cancer, in the laboratory, one strain (type 1) is able to drive white blood cells to become immortal better than the other (type 2).
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While scientists already knew that the different properties of the two strains were caused by a protein called EBNA2, which is produced by EBV, until now they didn't know how it could cause the viruses to act so differently.

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