The most common form of adult brain cancer is glioblastoma. Doctors diagnose about 14,000 glioblastoma cases in the U.S. each year. This aggressive cancer has claimed the lives of Senators John McCain and Edward Kennedy.
“Our body has armies of white blood cells that help us fight off bacteria, viruses and cancer cells. This constellation of cells constitute our immune system,” said senior author Clark C. Chen, MD, PhD, Lyle French Chair in Neurosurgery and Head of the Department of Neurosurgery at the University of Minnesota Medical School. “One of the key reasons why glioblastoma is so aggressive is that it shuts off this immune system.”
The importance of the immune system in cancer therapy is highlighted by the 2018 Nobel Prize in Physiology or Medicine. The prize was awarded to the discovery of a drug that activates the patient’s immune response against cancer cells. Treatment with this immunotherapy drug has produced impressive long-term survival in many cancer types. Unfortunately, this drug does not appear to work against glioblastomas.
“Immunotherapy works by activating the white blood cells that are present in many cancer types. For reasons that are not clear, glioblastomas contain few white blood cells. So, there is nothing for immunotherapy to activate,” commented Andrew Kummel, Professor of Chemistry and Biochemistry at the University of California San Diego and co-senior author of this study.