"Before the turn of the century, it was tradition to castrate men with high-risk or aggressive local prostate cancer with no signs of spreading, as the disease at that point was thought to be incurable," says Anders Widmark, senior physician and professor at Umeå University, who led the study.
"When we published the first results of this study in the Lancet in 2009, we contributed to changing the attitude towards radiotherapy for older patients with advanced prostate cancer. In this follow-up study, we present even more evident results that clearly show how patients who previously were considered incurable, to a large extent can be cured and that these patients should therefore be offered radiotherapy as an additional treatment."
In the study, which is also published in European Urology, researchers have compared a common Nordic pill-based hormone therapy (with so-called antiandrogen) and the same treatment method with the addition of local radiotherapy. The results of a long-term follow-up 15 years after diagnosis showed that treatments with the addition of radiotherapy halved the risk of patients dying from prostate cancer from 34 to 17 per cent.
Prostate cancer is the single-handedly most common type of cancer in Sweden with about 9,000 diagnosed patients per year. In Sweden, the traditional treatment is hormone therapy using antiandrogens that has fewer side-effects than castration. The hormone suppressing treatment slows down the growth of cancer cells by blocking the stimulating effect of testosterone.
"We are also in the process of evaluating how hormone therapy against prostate cancer affects the patients' quality of life. We will publish that study shortly," says Anders Widmark.
Fosså et al. Ten- and 15-yr prostate cancer-specific mortality in patients with nonmetastatic locally advanced or aggressive intermediate prostate cancer, randomized to lifelong endocrine treatment alone or combined with radiotherapy: final results of the scandinavian prostate cancer group-7. European Urolgy, 2016;DOI: 10.1016/j.eururo.2016.03.021 [Abstract]